At the Wake Forest Institute for Regenerative Medicine, Dr. Anthony Atala’s lab is the largest in the world “manufacturing” body parts. We’re not talking about prosthetics here, and not robotics – this is growing new, living organs – and they are yours – made up of identical tissue found in the rest of your body. Growing a finger from the ground up: layering cartilage, bone, then muscle. A beating, engineered heart valve that’s learning how to pump blood before it’s implanted. It’s regenerative medicine and the goal is to help the tens of thousands of people worldwide waiting for organ transplants. In Pittsburgh, Dr. Steven Badylak has discovered a compound that tricks the body into repairing itself, much like the body knows how to do when it’s in the womb. The U.S. military has invested $250 million in regenerative research aimed at helping soldiers with severe battle injuries, regrowing muscle and skin for burn injuries, as well as transplant technology for lost limbs.

Sourced & published by Henry Sapiecha

Researchers Reveal

Process of Making Ribs

ScienceDaily (Apr. 29, 2010) — Like all vertebrates, snakes, mice and humans have in common a skeleton made of segments, the vertebrae. But a snake has between 200-400 ribs extending from all vertebrae, from the neck to the tail-end, whereas mice have only 13 pairs of ribs, and humans have 12 pairs, in both cases making up the ribcage.

In the latest issue of Developmental Cell, researchers from the Instituto Gulbenkian de Ciência, in Portugal, reveal that, contrary to what was thought, making ribs is not the default state for vertebrates, but is actually an active process of balancing the activities of a remarkable class of genes — the Hox genes.

It was thought that the rib less region of the mouse embryo was the result of a rib-inhibiting programme, driven by Hox10 genes. Indeed, previous studies, in which Hox10 genes were inactivated in the embryo, generated mice with extra ribs. However, by forcing another class of Hox genes (Hox6) to be activated in future rib-less regions of the mouse embryo, Moises Mallo and his team bred mice that also have extra ribs, both in the neck area, and from just after the rib cage, all the way down to the tail, resembling a snake-like skeleton.

“It was an extraordinary, and clear-cut result,” says Mallo, “suggesting that these two groups of Hox genes balance each other out: one actively promotes rib formation to produce the thoracic region, while the other blocks this activity in the lumbar region. Our results have unveiled this balance.”

The researchers went on to unpick the genes involved in this process, and came up with yet another surprising finding: that the whole process relies on first hitting so-called muscle genes in the embryo, which then provide signals to switch on the ‘rib’ genes to make both ribs and muscle, in a coordinated process.

According to Mallo, “Our findings reveal a more complicated process than we would have imagined, but one that makes perfect sense, from a functional and evolutionary point of view: it is no good to make ribs without muscle, so, in the embryo, the production of both ribs and their associated muscles is under the control of a single and coordinated mechanism.”

Sourced and published by Henry Sapiecha 29th April 2010